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TISOL EYE DROP Description
Tisol (Ofloxacin) Eye Drops is a sterile Ophthalmic preparation of Ofloxacin, a potent broad spectrum synthetic antibacterial agent belonging to fluoroquinolone groupComposition
| Ofloxacin USP |
0.3% |
w/v |
| Sterile isotonic aqueous vehicle q.s. |
| Preservative : Benzalkonium Chloride |
| USNF |
0.01% |
w/v |
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TISOL Eye Drops is an effectfrive and safe antibacterial preparation for the management of external ocular bacterial infection viz. (a) bacterial keratitis caused by susceptible strains of P.aeruginosa, Propionibacterium acnes, Serratia marcescens, Staph. aureus, S.epidermidis, Strep.pneumoniae, and (b) conjunctivitis caused by susceptible strains like H.influenzae, P.aeruginosa, S.epidermidis, Strep.pneumoniae,Staph.aureus, etc.
TISOL Eye Drops containing Ofloxacin, is bacterial in action. Like other fluoroquinolones, Ofloxacin inhibits DNA topoisomerase (Type II ), generally referred to as DNA gyrase, in susceptible organisms. DNA gyrase is essential for bacterial DNA replication, repair, recombination, transposition. Inhibition of DNA gyrase results in inhibition of ATP dependent negative supercoiling of DNA, inhibition of ATP independent relaxation of supercoiled DNA, and promotion of double stranded DNA breakage.
The extent of ocular and systemetic absorption of Ofloxacon following topical application to the eye has not been fully elucidated; however serum concentrations achieved following such application to uninflammed eyes are minimal relative to those produced by oral parenteral doses of the drug. Ofloxacin is absorbed through the cornea into aqueous humor following topical application to the eye; the absorption is enhanced in the presence of ocular inflammation and/or epithelial defects Followinf topical application to the eye of 2 drops of a 0.3% solution of Ofloxacin every 30 minutes beginning 4 hours before surgery, in patients undergoing keratoplasty, corneal tissue, aqueous humor, vitreous
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